Olejar Books

Cancer killed 6.7 million people around the world in 2002, and this figure is expected to rise to 10.1 million in 2020. Approximately, 189,510 new cases of breast cancer were reported in 2007 in the United States, and 40,910 died in the same year. Both principles and practice of breast oncology are presented in this volume. Node negative breast cancer, sebaceous cancer of the breast, phyllodes tumors of the breast, metaplastic breast cancer, invasive breast cancer, and multifocal and multicenter breast cancers are discussed. Breast cancer detection is explained using high throughput, MicroRNA expression, computer-aided detection, in vivo imaging of angiogenesis, contrast-enhanced digital mammography, sentinel node biopsy, and cytology in nipple-aspirated fluid. Validation of breast cancer biomarkers using tissue microarrays, epigenetic markers in blood, and HER-2 and EGFR expression. Role of BRCA1 and BRCA2 genes and their protein products in breast cancer is included. Also are discussed breast cancer recurrence, detection of circulating cancer cells, and prediction of metastasis. Breast conserving therapy versus Mastectomy is compared. Multimodality treatment, palliative treatment, and neoadjuvant therapy are discussed in detail.