Olejar Books

This volume presents a cross section of recent advances in the development of novel chemical and biochemical sensors for on-line monitoring and control applications in the environmental, clinical, and bioprocess areas. These chapters illustrate how many of the key challenges for continuous monitoring are being addressed. The methods discussed include optical techniques ranging from near-infrared spectroscopy to lifetime-based phase fluorometry; biosensors ranging from optical immunosensors to enzyme-electrodes; as well as electrochemical, acoustic, and plasmon resonance techniques.
The chapters in this book have been divided into two sections, “Biosensor Methods” (Chapter 1-8) and “Bioprocess Monitoring and Control” (Chapters 9–16). Chapters 1-8 discuss the development of methods that rely on biomolecular recognition for detection of target analytes for potential environmental and bioprocess monitoring applications. Recognition elements primarily include enzymes, antibodies, microorganisms, and DNA. These elements have been interfaced to electrochemical, optical, and acoustic sensors. The range of potential analytes is broad, and many of these methods can be modified to accommodate the measurement of additional analytes through the introduction of new enzymes or antibodies.
Chapters 9–16 cover the application of optical and biosensor methods for on-line monitoring and control of bioprocesses. Topics include the the use of expert systems for controlling flow injection analysis systems and hybrid process modeling for bioprocess control.